Clinical Consequences of Altered Drug Disposition in Obesity

Copyright: © 2012 Ghose R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Obesity is a major health problem in the United States and worldwide. About 30% of the population in the US is obese (Body Mass Index [BMI]>30 kg/m2), while ~5% of the population is morbidly obese (BMI >40 kg/m2) [1,2]. Obesity and morbid obesity are associated with changes in metabolism and clearance of drugs. This can increase the risks of adverse drug reactions and drug-drug interactions in obese individuals.